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Showing 1–11 of 11 results
Advanced filters: Author: Heather J. Faust Clear advanced filters

  • Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

    • Heather J. Faust
    • Tan-Yun Cheng
    • Michael B. Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

    • Erin M. Buchanan
    • Kelly Cuccolo
    • Savannah C. Lewis
    Research
    Nature Human Behaviour
    Volume: 10, P: 182-201

  • A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

    • Antonia Ho
    • Richard Orton
    • Emma C. Thomson
    Research
    Nature
    Volume: 617, P: 555-563

  • Most DNA-encoded library (DEL) syntheses are limited by the presence of sensitive DNA-based constructs. Here, the authors develop DOSEDO, a diverse 3.7 million compound DEL, generated through diversity-oriented synthesis that provides enhanced scaffold and exit vector diversity and gives validated binding hits for multiple protein targets.

    • Liam Hudson
    • Jeremy W. Mason
    • Karin Briner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

    • Barbara A. Methé
    • Karen E. Nelson
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 215-221

  • Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

    • Roger L Milne
    • Karoline B Kuchenbaecker
    • Jacques Simard
    Research
    Nature Genetics
    Volume: 49, P: 1767-1778

  • The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

    • Curtis Huttenhower
    • Dirk Gevers
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 207-214