Nature Search

High-resolution genomic history of early medieval Europe

Twigstats, a method for ancestry reconstruction, provides high-resolution genetic histories and movement patterns of people living in Europe during the first millennium ce.

Leo Speidel
Marina Silva
Pontus Skoglund
ResearchOpen Access01 Jan 2025
Nature

Volume: 637, P: 118-126
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
South-to-north migration preceded the advent of intensive farming in the Maya region

The genetic prehistory of central America has not been well explored. Here, the authors find evidence from ancient DNA from twenty individuals who lived in Belize 9,600 to 3,700 years ago of a migration from the south that coincided with the first evidence for forest clearing and the spread of maize horticulture.

Douglas J. Kennett
Mark Lipson
David Reich
ResearchOpen Access22 Mar 2022
Nature Communications

Volume: 13, P: 1-10
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
Common variants at 30 loci contribute to polygenic dyslipidemia

Sekar Kathiresan et al. report genome-wide association studies for polygenic dyslipidemia. From a meta-analysis of seven genome-wide association studies and follow-up in five replication studies, they identify 11 new genetic associations for LDL cholesterol, HDL cholesterol and triglycerides.

Sekar Kathiresan
Cristen J Willer
L Adrienne Cupples
Research07 Dec 2008
Nature Genetics

Volume: 41, P: 56-65
Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems

Long-term grassland and forest experiments reveal that temporal strengthening in biodiversity functioning relationships is mainly driven by increases in functioning in high-diversity communities.

Nathaly R. Guerrero-Ramírez
Dylan Craven
Nico Eisenhauer
Research02 Oct 2017
Nature Ecology & Evolution

Volume: 1, P: 1639-1642
Plant functional trait change across a warming tundra biome

Analyses of the relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.

Anne D. Bjorkman
Isla H. Myers-Smith
Evan Weiher
Research26 Sept 2018
Nature

Volume: 562, P: 57-62
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

Karen Mohlke, Markku Laakso, Michael Boehnke and colleagues report the first application of the Illumina HumanExome Beadchip array, examining association with insulin and glycemic traits in 8,229 nondiabetic Finnish males from the population-based Metabolic Syndrome in Men (METSIM) study. They identify low-frequency coding variants at both known and newly associated loci with insulin processing and secretion.

Jeroen R Huyghe
Anne U Jackson
Karen L Mohlke
Research23 Dec 2012
Nature Genetics

Volume: 45, P: 197-201
Author Correction: Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems

Nathaly R. Guerrero-Ramírez
Dylan Craven
Nico Eisenhauer
Amendments and Corrections08 Aug 2019
Nature Ecology & Evolution

Volume: 3, P: 1365-1366
Multiple loci identified in a genome-wide association study of prostate cancer

Gilles Thomas
Kevin B Jacobs
Stephen J Chanock
Research10 Feb 2008
Nature Genetics

Volume: 40, P: 310-315
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several previously reported breast cancer risk loci.

Gilles Thomas
Kevin B Jacobs
David J Hunter
Research29 Mar 2009
Nature Genetics

Volume: 41, P: 579-584
Defining subgroups of pediatric nephrotic patients with urine proteomics

Timothy D. Cummins
Laura H. Mariani
Lisa M. Guay-Woodford
ResearchOpen Access11 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
The pathogenesis of IgA nephropathy and implications for treatment

IgA nephropathy (IgAN) is thought to result from multiple hits that culminate in immune complex deposition in the kidney. Here, the authors describe the latest insights into the pathogenesis of IgAN and how they have revealed novel therapeutic targets and approaches to this disease.

Chee Kay Cheung
Suceena Alexander
Jonathan Barratt
Reviews04 Sept 2024
Nature Reviews Nephrology

Volume: 21, P: 9-23
Genome-wide detection and characterization of positive selection in human populations

Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

Pardis C. Sabeti
Patrick Varilly
John Stewart
Research18 Oct 2007
Nature

Volume: 449, P: 913-918
Wisdom of crowds for robust gene network inference

This analysis comprehensively compares methods for gene regulatory network inference submitted through the DREAM5 challenge. It demonstrates that integration of predictions from multiple methods shows the most robust performance across data sets.

Daniel Marbach
James C Costello
Gustavo Stolovitzky
Research15 Jul 2012
Nature Methods

Volume: 9, P: 796-804
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial

Phuong T. Vu
Robin K. Ohls
John A. Widness
Research11 Jan 2021
Pediatric Research

Volume: 90, P: 109-116

Search

High-resolution genomic history of early medieval Europe

Genomic investigations of unexplained acute hepatitis in children

South-to-north migration preceded the advent of intensive farming in the Maya region

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Common variants at 30 loci contribute to polygenic dyslipidemia

Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems

Plant functional trait change across a warming tundra biome

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

Author Correction: Diversity-dependent temporal divergence of ecosystem functioning in experimental ecosystems

Multiple loci identified in a genome-wide association study of prostate cancer

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

Defining subgroups of pediatric nephrotic patients with urine proteomics

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

The pathogenesis of IgA nephropathy and implications for treatment

Genome-wide detection and characterization of positive selection in human populations

Wisdom of crowds for robust gene network inference

Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial

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