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Showing 1–6 of 6 results

Advanced filters: Author: Heidi Dvinge Clear advanced filters

Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Stanley Chun-Wei Lee
Heidi Dvinge
Omar Abdel-Wahab
Amendments and Corrections07 Jun 2016
Nature Medicine

Volume: 22, P: 692
The shaping and functional consequences of the microRNA landscape in breast cancer

MicroRNA profiling of 1,302 human breast tumour samples provides an overview of the miRNA landscape and its regulation, revealing context-dependent interactions, broad prognostic value of miRNA signatures and an important modulatory role for miRNAs in the biology of breast tumours devoid of copy-number aberrations.

Heidi Dvinge
Anna Git
Carlos Caldas
Research05 May 2013
Nature

Volume: 497, P: 378-382
RNA splicing factors as oncoproteins and tumour suppressors

This Review discusses the current genetic and functional links between dysregulated and/or mutated RNA splicing factors and cancer, as well as the therapeutic opportunities presented by alterations in alternative splicing in cancer.

Heidi Dvinge
Eunhee Kim
Robert K. Bradley
Reviews10 Jun 2016
Nature Reviews Cancer

Volume: 16, P: 413-430
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Leukemias bearing heterozygous mutations in the SRSF2 splicing-factor-encoding gene can be therapeutically targeted by pharmacologic inhibition of residual spliceosome function.

Stanley Chun-Wei Lee
Heidi Dvinge
Omar Abdel-Wahab
Research02 May 2016
Nature Medicine

Volume: 22, P: 672-678
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

Analyses of transcriptomes from patients with acute myeloid leukaemia identified frequently co-occurring mutations of IDH2 and SRSF2, which functional analyses showed to have distinct and coordinated leukaemogenic effects on the epigenome and RNA splicing.

Akihide Yoshimi
Kuan-Ting Lin
Omar Abdel-Wahab
Research02 Oct 2019
Nature

Volume: 574, P: 273-277
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

In prostate cancer, the oncogenicity of transcription factor ERG is mediated, in part, by competition with another member of the ETS family, ERF.

Rohit Bose
Wouter R. Karthaus
Charles L. Sawyers
Research14 Jun 2017
Nature

Volume: 546, P: 671-675