Hoogsteen (HG) base pairs occur transiently within DNA and exhibit altered non Watson–Crick (WC)-pairing geometries with the potential to govern sequence-dependent DNA processes. Here, Alvey et al.show that HG base pairing occurs within diverse sequence contexts and define the energetic landscapes that favour WC-to-HG transitions.
- Heidi S. Alvey
- Federico L. Gottardo
- Hashim M. Al-Hashimi
