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Advanced filters: Author: Heike Stephanowitz Clear advanced filters

Structural basis of phosphatidylinositol 3-kinase C2α function

High-resolution structures of phosphatidylinositol 3-kinase (PI3K) type IIa unravel a coincident mechanism of lipid-induced enzyme activation and enable the development of inhibitors of class II PI3K function with applications in biomedicine.

Wen-Ting Lo
Yingyi Zhang
Volker Haucke
ResearchOpen Access07 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 218-228
Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

Carola Mancini
Sabrina Gohlke
Tim J. Schulz
ResearchOpen Access07 Oct 2021
Scientific Reports

Volume: 11, P: 1-15

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Structural basis of phosphatidylinositol 3-kinase C2α function

Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways

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