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Showing 1–9 of 9 results
Advanced filters: Author: Helen S. Goodridge Clear advanced filters

  • Clinical evidence, including results from randomized controlled clinical trials, strongly suggests that certain live vaccines can reduce all-cause mortality, most probably through protection against non-targeted pathogens. This Opinion article examines the potential immunological mechanisms underlying these effects.

    • Helen S. Goodridge
    • S. Sohail Ahmed
    • Christopher B. Wilson
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 392-400

  • MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.

    • Júlia Aguadé-Gorgorió
    • Yasaman Jami-Alahmadi
    • Hanna K. A. Mikkola
    ResearchOpen Access
    Nature
    Volume: 630, P: 412-420

  • A single-cell transcriptomic analysis of endometriosis, endometriomas, eutopic endometrial samples and uninvolved ovary tissues highlights cell populations characteristic of these tissue types. Transcriptional and cellular heterogeneity across tissues suggests novel therapeutic targets and biomarkers for this disease.

    • Marcos A. S. Fonseca
    • Marcela Haro
    • Kate Lawrenson
    Research
    Nature Genetics
    Volume: 55, P: 255-267

  • Research from Helen Goodridge and Clive Svendsen’s groups published in Communications Biology showed that young bone marrow transplantation slows down cognitive decline in old mice. The authors now discuss subsequent studies examining the relationship between blood components and aging-associated cognitive impairment and rejuvenation as well as their own ongoing work.

    • Seokjo Kang
    • V. Alexandra Moser
    • Helen S. Goodridge
    Comments & OpinionOpen Access
    Communications Biology
    Volume: 3, P: 1-4

  • Phagocytosis is an important innate defence mechanism, and there is more to this process than merely engulfing a pathogen. This Review discusses how myeloid cells integrate the various distinct signals that they receive during phagocytosis in order to promote an appropriate immune response to the threat at hand.

    • David M. Underhill
    • Helen S. Goodridge
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 492-502

  • Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.

    • Alberto Yáñez
    • Helen S Goodridge
    • H Leighton Grimes
    News & Views
    Nature Immunology
    Volume: 18, P: 872-873

  • Melanie Das et al. demonstrate that transplantation of young bone marrow preserves the cognitive function of old recipient mice. This study suggests that microglial rejuvenation via peripheral manipulation of the hematopoietic system may be sufficient to delay a cognitive decline during aging.

    • Melanie M. Das
    • Marlesa Godoy
    • Helen S. Goodridge
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10