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Showing 1–2 of 2 results
Advanced filters: Author: Helena Borràs-Gas Clear advanced filters

  • SUMO modification regulates protein function, with SENP enzymes controlling SUMO removal. Here, the authors present crystal structures of SENP5 bound to SUMO1 and SUMO2, revealing how structural features drive its preference for SUMO2 and offering insights into SUMOylation regulation.

    • Lucía Sánchez-Alba
    • Li Ying
    • David Reverter
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Nse2 is a SUMO E3 ligase component of the Smc5/6 multisubunit complex involved in the DNA repair and chromosome integrity. Here, the structure of the Nse2 in complex with an E2-SUMO thioester mimetic reveals the combined action of two SIM motifs during the E3- dependent conjugation reaction.

    • Nathalia Varejão
    • Jara Lascorz
    • David Reverter
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14