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Showing 1–5 of 5 results

Advanced filters: Author: Helene Damhofer Clear advanced filters

WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth

With-No-lysine (K) kinase 1 (WNK1) is an atypical serine-threonine kinase that has been implicated in ion transport. Here, the authors show that WNK1 regulates amino acid transport and mTORC1 activity, and that the axis is a vulnerability for acute myeloid leukemia

Shunlei Duan
Karl Agger
Kristian Helin
ResearchOpen Access27 May 2025
Nature Communications

Volume: 16, P: 1-18
EZH2i unlocks PDAC immune surveillance

Successful immune-mediated tumor control in pancreatic cancer is severely hampered by its dense desmoplastic stroma. New work shows that EZH2 inhibition relieves the suppressive effect of tumor stroma on pro-inflammatory chemokine expression after therapy-induced senescence, boosting NK and T cell recruitment and immunological tumor control.

Helene Damhofer
Kristian Helin
News & Views27 Jun 2023
Nature Cancer

Volume: 4, P: 781-783
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Although mechanisms wherein pre-existing H3K27 methylation directs recruitment of PRC2 to support its own maintenance have been proposed, H3K27 methylation patterns in mESCs are not dependent on self-autonomous epigenetic inheritance.

Jonas W. Højfeldt
Anne Laugesen
Kristian Helin
Research26 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 225-232
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Helene Damhofer
Tülin Tatar
Kristian Helin
ResearchOpen Access17 Apr 2024
Cell Death & Disease

Volume: 15, P: 1-17
Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems

Frederike Dijk
Veronique L. Veenstra
Maarten F. Bijlsma
ResearchOpen Access15 Jan 2020
Scientific Reports

Volume: 10, P: 1-12