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Author Correction: Every step of the way: integrins in cancer progression and metastasis

Hellyeh Hamidi
Johanna Ivaska
Amendments and Corrections31 Jan 2019
Nature Reviews Cancer

Volume: 19, P: 179
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

The multidomain scaffold protein SH3 and multiple ankyrin repeat domain 3 (SHANK3) can bind GTP-bound Ras and Rap small GTPases. Here the authors show that, by binding active KRAS, SHANK3 maintains oncogenic KRAS/MAPK/ERK signaling at an optimal level while its depletion in KRAS-mutant cancer cell lines results in ERK signalling overdose and impaired cell proliferation.

Johanna Lilja
Jasmin Kaivola
Johanna Ivaska
ResearchOpen Access12 Sept 2024
Nature Communications

Volume: 15, P: 1-20
Every step of the way: integrins in cancer progression and metastasis

In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of integrins and novel opportunities to target integrin signalling.

Hellyeh Hamidi
Johanna Ivaska
Reviews12 Jul 2018
Nature Reviews Cancer

Volume: 18, P: 533-548
Integrin trafficking in cells and tissues

Moreno-Layseca et al. discuss how integrins, key receptors that mediate cell adhesion to the extracellular matrix, are endocytosed and recycled to the cell surface to modulate cell and tissue behaviour.

Paulina Moreno-Layseca
Jaroslav Icha
Johanna Ivaska
Reviews02 Jan 2019
Nature Cell Biology

Volume: 21, P: 122-132
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

Lilja et al. find that SHANK proteins inhibit the signalling of Ras and Rap G-proteins by restricting their availability at the plasma membrane. This leads to restricted integrin activation, affecting cell spreading, migration and invasion.

Johanna Lilja
Thomas Zacharchenko
Johanna Ivaska
Research06 Mar 2017
Nature Cell Biology

Volume: 19, P: 292-305
The complexity of integrins in cancer and new scopes for therapeutic targeting

Hellyeh Hamidi
Mika Pietilä
Johanna Ivaska
ReviewsOpen Access29 Sept 2016
British Journal of Cancer

Volume: 115, P: 1017-1023
Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

This protocol describes how to produce cell-derived matrices from fibroblasts. These matrices can be used to provide a 3D scaffold for cell culture and to investigate cell behavior in complex microenvironments.

Riina Kaukonen
Guillaume Jacquemet
Johanna Ivaska
Protocols19 Oct 2017
Nature Protocols

Volume: 12, P: 2376-2390

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Author Correction: Every step of the way: integrins in cancer progression and metastasis

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

Every step of the way: integrins in cancer progression and metastasis

Integrin trafficking in cells and tissues

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

The complexity of integrins in cancer and new scopes for therapeutic targeting

Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

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