We report the preparation of novel functional microparticles by self-assembly of amphiphilic copolymer composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and dodecylamine (DOA) as a hydrophobic side chain (γ-PGA-DOA). γ-PGA-DOA with a grafting degree of 55% self-assembled by hydrophobic interaction, and formed microparticles (diameter 13±3 μm) in aqueous solution. These microparticles possess functional carboxylic groups, and could be further modified with active compounds such as drugs, proteins and peptides, and thus have great potential as vaccine carriers.
- Fumiaki Shima
- Bjoern Schulte
- Mitsuru Akashi
