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Showing 1–3 of 3 results
Advanced filters: Author: Hemalatha Balaram Clear advanced filters

  • Succinimide is a post-translational modification susceptible to rapid hydrolysis and generally associated with protein destabilisation. Here, the authors use mass spectroscopy to identify a stable succinimide intermediate that is responsible for the high thermostability of a thermophilic enzyme.

    • Sanjeev Kumar
    • Sunita Prakash
    • Hemalatha Balaram
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ligand-free state and bound to either IMP or ATP.

    • Loïc Carrique
    • Lionel Ballut
    • Nushin Aghajari
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • GMP synthetase, a key enzyme in purine biosynthesis, is of interest for understanding purine metabolism processes and for developing therapeutic applications. Here, the authors propose a molecular mechanism and the structural basis for the catalytic activity of this enzyme.

    • Lionel Ballut
    • Sébastien Violot
    • Nushin Aghajari
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13