Mitochondria influence cellular proteostasis, though the proteins that mediate this role are not well described. Here they show that the mitochondrial protein MFN2 interacts with the proteasome and with chaperones to coordinate protein quality control in the cytoplasm, gate-keeping protein aggregation in cell lines of patients with neurodegeneration.
- Mariana Joaquim
- Selver Altin
- Mafalda Escobar-Henriques
