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Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy

Immune checkpoint blockade therapy improved the survival rates of non-small cell lung cancer but only a proportion of patients benefit. Here authors follow the humoral and cellular immunological parameters of patients undergoing anti-PD1 therapy longitudinally and find that levels and functional properties of cytotoxic T cells, and especially CD8⁺CD101^hiTIM3⁺ cells determine the response.

Elaine Lai-Han Leung
Run-Ze Li
Liang Liu
ResearchOpen Access22 Aug 2023
Nature Communications

Volume: 14, P: 1-9
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

The progenitor stage of commitment toward the conventional dendritic cell subsets and the transcriptional networks that control it remain poorly understood. Two articles from Ginhoux and colleagues and Murphy and colleagues offer insight into these processes.

Andreas Schlitzer
V Sivakamasundari
Florent Ginhoux
Research08 Jun 2015
Nature Immunology

Volume: 16, P: 718-728
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

Naomi McGovern
Amanda Shin
Florent Ginhoux
Research14 Jun 2017
Nature

Volume: 546, P: 662-666
High-dimensional analysis of the murine myeloid cell system

Myeloid cells show great phenotypic and functional diversity. Newell and colleagues use mass cytometry with a panel of 38 mouse myeloid markers to describe myeloid cell phenotypic diversity in unprecedented depth within eight different tissues.

Burkhard Becher
Andreas Schlitzer
Evan W Newell
Research12 Oct 2014
Nature Immunology

Volume: 15, P: 1181-1189

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Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

High-dimensional analysis of the murine myeloid cell system

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