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Showing 1–2 of 2 results
Advanced filters: Author: Hidehito Yoshihara Clear advanced filters

  • Phosphorylation of insulin receptor substrate (IRS)-1/2 by insulin-like growth factor (IGF)-I receptor tyrosine kinase is essential for IGF signalling. Here, the authors show that monoubiquitination of IRS-2 by the ubiquitin ligase Nedd4 recruits IRS-2 to the cell membrane and increases IRS-2 phosphorylation and IGF signalling.

    • Toshiaki Fukushima
    • Hidehito Yoshihara
    • Shin-Ichiro Takahashi
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • Ubiquitin, known for its role in post-translational modification of other proteins, undergoes post-translational modification itself; after a decrease in mitochondrial membrane potential, the kinase enzyme PINK1 phosphorylates ubiquitin at Ser 65, and the phosphorylated ubiquitin then interacts with ubiquitin ligase (E3) enzyme parkin, which is also phosphorylated by PINK1, and this process is sufficient for full activation of parkin enzymatic activity.

    • Fumika Koyano
    • Kei Okatsu
    • Noriyuki Matsuda
    Research
    Nature
    Volume: 510, P: 162-166