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Advanced filters: Author: Hillary Dimig Clear advanced filters

  • CRISPR-Cas enzymes are increasingly entering clinical trials for gene therapies but can sometimes alter DNA off-target. We present an approach to modify the guide RNA to effectively eliminate off-target activity for target sequences of interest.

    • Ashley Herring-Nicholas
    • Hillary Dimig
    • Eric A. Josephs
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-9