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GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

Glycerophosphodiesterase 7 is demonstrated to be responsible for production of cyclic phosphatidic acid in the ER lumen, which functions as a lipid mediator suppressing nuclear peroxisome proliferator-activated receptor γ.

Keisuke Kitakaze
Hanif Ali
Kazuhito Tsuboi
ResearchOpen Access16 May 2023
Communications Biology

Volume: 6, P: 1-12

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GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

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