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Showing 1–3 of 3 results
Advanced filters: Author: Hironobu Murata Clear advanced filters

  • Therapeutic proteins are often conjugated with polymers, but separating the conjugate from unconjugated protein and free polymer is a major challenge. Here, the authors discover that proteins conjugated to charged or zwitterionic polymers maintain solubility in 100% ammonium sulfate, greatly simplifying purification.

    • Stefanie L. Baker
    • Aravinda Munasinghe
    • Alan J. Russell
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins reversibly on modified agarose beads before grafting from polymers via ATRP.

    • Hironobu Murata
    • Sheiliza Carmali
    • Alan J. Russell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Yoshihiro Onouchi and colleagues report the results of a genome-wide association study of Kawasaki disease. They identify three new risk loci, all mapping near genes previously implicated in adult-onset autoimmune diseases.

    • Yoshihiro Onouchi
    • Kouichi Ozaki
    • Adriana H Tremoulet
    Research
    Nature Genetics
    Volume: 44, P: 517-521