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Showing 1–50 of 59 results

Advanced filters: Author: Hiroshi Mitani Clear advanced filters

A Laser Scattering Photogoniometer

Yoshiyuki Einaga
Tetsuo Mitani
Hiroshi Fujita
Research01 Jul 1979
Polymer Journal

Volume: 11, P: 565-574
Enhanced spin accumulation and novel magnetotransport in nanoparticles

Kay Yakushiji
Franck Ernult
Hiroyasu Fujimori
Research05 Dec 2004
Nature Materials

Volume: 4, P: 57-61
Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology

Yasumasa Mitani
Alexander Lezhava
Yoshihide Hayashizaki
Research18 Feb 2007
Nature Methods

Volume: 4, P: 257-262
AML1(−/−) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene

Hitoshi Okada
Toshio Watanabe
Masanobu Satake
Research10 Oct 1998
Oncogene

Volume: 17, P: 2287-2293
IL-17-producing γδ T cells enhance bone regeneration

γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.

Takehito Ono
Kazuo Okamoto
Hiroshi Takayanagi
ResearchOpen Access11 Mar 2016
Nature Communications

Volume: 7, P: 1-9
Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling

Targetting tumour angiogenesis is a useful strategy to reduce tumour burden; however, the clinical benefits of anti-angiogenetic drugs are modest. Here, the authors show that HGFR signalling, which contributes to tumour angiogenesis, requires Arf6 and that blocking Arf6 can lead to reduced tumour growth in mice.

Tsunaki Hongu
Yuji Funakoshi
Yasunori Kanaho
Research04 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.

Shunsuke Hasegawa
Hotaka Fukushima
Satoshi Kida
ResearchOpen Access18 Dec 2019
Nature Communications

Volume: 10, P: 1-14
p63 is a cereblon substrate involved in thalidomide teratogenicity

Zebrafish p63 isoforms were identified as thalidomide-dependent neosubstrates of the cereblon-containing E3 ligase complex. ∆Np63α and TAp63α are responsible for thalidomide-induced malformations of pectoral fins and otic vesicles, respectively.

Tomoko Asatsuma-Okumura
Hideki Ando
Hiroshi Handa
Research07 Oct 2019
Nature Chemical Biology

Volume: 15, P: 1077-1084
RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

It is shown that type of repair pathway, known as postreplication repair, permits cells to replicate their DNA when it is damaged, thereby avoiding the activation of a cellular response that would inhibit proliferation.

Takashi Hishida
Yoshino Kubota
Hiroshi Iwasaki
Research14 Dec 2008
Nature

Volume: 457, P: 612-615
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice

Toshimasa Yamauchi
Yuichi Oike
Takashi Kadowaki
Research30 Jan 2002
Nature Genetics

Volume: 30, P: 221-226
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis

The protein Mincle can sense pathogens and molecules associated with cell death. Here the authors show that Mincle expressed in macrophages is a mediator of obesity-induced fibrosis and inflammation of adipose tissue, and that Mincle knockout mice are protected from diet-induced metabolic dysfunction.

Miyako Tanaka
Kenji Ikeda
Yoshihiro Ogawa
Research19 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

Motomasa Tanaka
Yoko Machida
Nobuyuki Nukina
Research18 Jan 2004
Nature Medicine

Volume: 10, P: 148-154
Structural basis for high selectivity of a rice silicon channel Lsi1

The rice Lsi1 aquaporin mediates uptake of silicic acid via the roots. Here the authors show the crystal structure of rice Lsi1 and characterize a unique five residue hydrophilic selectivity filter providing a structural basis for the highly selective activity of Lsi1 in Si uptake.

Yasunori Saitoh
Namiki Mitani-Ueno
Michihiro Suga
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans

Souhei Mizuguchi
Toru Uyama
Kazuya Nomura
Research22 May 2003
Nature

Volume: 423, P: 443-448
Giant spin Hall effect in perpendicularly spin-polarized FePt/Au devices

Takeshi Seki
Yu Hasegawa
Koki Takanashi
Research13 Jan 2008
Nature Materials

Volume: 7, P: 125-129
Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone

Asano et al. dissect the functional difference between the soluble and membrane-bound forms of RANKL. Membrane-bound RANKL is sufficient for most physiological RANKL functions, whereas soluble RANKL promotes bone metastases by stimulating tumour cell migration to bone, without affecting tumour cell growth or osteoclast differentiation.

Tatsuo Asano
Kazuo Okamoto
Hiroshi Takayanagi
Research02 Sept 2019
Nature Metabolism

Volume: 1, P: 868-875
Direct plasma treatment of caryopses after flowering in brewer’s rice cultivar Yamadanishiki enhanced those grain qualities through “Smart Agriculture System”

Hiroshi Hashizume
Hidemi Kitano
Masaru Hori
ResearchOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
Clonal hematopoiesis in adult pure red cell aplasia

Naohito Fujishima
Junki Kohmaru
Makoto Hirokawa
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-7
Continuous infusion of PTH_1–34 delayed fracture healing in mice

Kiminori Yukata
Tsukasa Kanchiku
Natsuo Yasui
ResearchOpen Access04 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Chizuru Yabumoto
Hiroshi Akazawa
Issei Komuro
ResearchOpen Access25 Sept 2015
Scientific Reports

Volume: 5, P: 1-15
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

The microtubule plus end protein CLIP-170 has been shown to be an AMP activated protein kinase (AMPK) substrate. AMPK-mediated phosphorylation of CLIP-170 regulates microtubule polarization and directional cell migration.

Atsushi Nakano
Hisakazu Kato
Seiji Takashima
Research23 May 2010
Nature Cell Biology

Volume: 12, P: 583-590
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage.

Takuma Hashimoto
Daiki D. Horikawa
Takekazu Kunieda
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-14
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Yasuaki Kabe
Daisuke Takemoto
Makoto Suematsu
ResearchOpen Access20 Feb 2020
npj Science of Food

Volume: 4, P: 1-12
Structural Investigation of Iron(III) and Copper(II) Complexes with Poly(vinyl alcohol) by NMR Techniques

Yasuyoshi Mori
Hiroshi Yokoi
Yutaka Fujise
Research01 Mar 1995
Polymer Journal

Volume: 27, P: 271-279
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)

Rurika Okuda
Yotaro Ochi
Seishi Ogawa
ResearchOpen Access23 Dec 2024
Leukemia

Volume: 39, P: 760-764
Role of Chymase-Dependent Angiotensin II Formation in Monocrotaline-Induced Pulmonary Hypertensive Rats

Kanta Kishi
Denan Jin
Mizuo Miyazaki
Research01 Jul 2006
Pediatric Research

Volume: 60, P: 77-82
N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I

Shinoda and Kitakaze et al. prepared recombinant hIDUA from transgenic silkworm cocoons and transglycosylated to mannose-6-phosphate- or α2,6-sialyl glycan-type using ENGases. These enzymes were administrated to a mucopolysaccharidosis type I macaque and succeeded in improving the clinical signs and reducing the urinary glycosaminoglycan levels.

Chika Shinoda
Keisuke Kitakaze
Kohji Itoh
ResearchOpen Access18 Apr 2025
Communications Medicine

Volume: 5, P: 1-14
Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration

Kenichi Mishima
Yuka Tsukagoshi Okabe
Shiro Imagama
ResearchOpen Access29 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation

Nadia Kartikasari
Masahiro Yamada
Hiroshi Egusa
ResearchOpen Access18 Jul 2022
Scientific Reports

Volume: 12, P: 1-18
Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling

Takehito Ono
Ryosuke Denda
Tomoki Nakashima
ResearchOpen Access03 Aug 2022
Bone Research

Volume: 10, P: 1-14
LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats

Toru Miyoshi
Kazufumi Nakamura
Hiroshi Ito
ResearchOpen Access23 Mar 2022
Scientific Reports

Volume: 12, P: 1-13
Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging

Kazuo Yamagata
Kouhei Nagai
Akira Iritani
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Chymase Inhibition Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction in Rats

Hideo Kanemitsu
Shinji Takai
Masashi Komeda
Research01 Jan 2006
Hypertension Research

Volume: 29, P: 57-64
Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

Qi Guo
Takefumi Mori
Sadayoshi Ito
ResearchOpen Access08 Sept 2011
Hypertension Research

Volume: 35, P: 48-54
Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat

Kenji Miyamoto
Yasunori Kitamoto
Kimio Tomita
Research14 Jun 2004
Laboratory Investigation

Volume: 84, P: 1126-1136
Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension

Masaki Ryuzaki
Atsuhiro Ichihara
Hiroshi Itoh
Research25 Nov 2010
Hypertension Research

Volume: 34, P: 301-307
Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization

Takatoshi Sato
Yoshitaka Iso
Hiroshi Suzuki
Research31 Jan 2011
Laboratory Investigation

Volume: 91, P: 553-564
A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing

The authors developed a CUBIC tissue clearing and expansion method to generate an editable, point-based single-cell-resolution brain atlas. This atlas, termed CUBIC-Atlas, can be used for unbiased systems-level cellular analysis in whole mouse brain.

Tatsuya C. Murakami
Tomoyuki Mano
Hiroki R. Ueda
Research05 Mar 2018
Nature Neuroscience

Volume: 21, P: 625-637
Peroxisome proliferator-activated receptor alpha agonist suppresses neovascularization by reducing both vascular endothelial growth factor and angiopoietin-2 in corneal alkali burn

Takeshi Arima
Masaaki Uchiyama
Hiroshi Takahashi
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-11
Bone regeneration by polyhedral microcrystals from silkworm virus

Goichi Matsumoto
Takayo Ueda
Hajime Mori
ResearchOpen Access06 Dec 2012
Scientific Reports

Volume: 2, P: 1-7
Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1

Naoki Muguruma
Koichi Okamoto
Tetsuji Takayama
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Chondroitin Sulfate Is Indispensable for Pluripotency and Differentiation of Mouse Embryonic Stem Cells

Tomomi Izumikawa
Ban Sato
Hiroshi Kitagawa
ResearchOpen Access15 Jan 2014
Scientific Reports

Volume: 4, P: 1-12
Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome

Hiroshi Kida
Tomoyuki Takahashi
Toyojiro Matsuishi
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis

Akihiro Katayama
Atsuko Nakatsuka
Jun Wada
ResearchOpen Access19 Nov 2015
Scientific Reports

Volume: 5, P: 1-15
In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model

Kento Nagata
Chika Hashimoto
Hiroshi Mitani
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Advanced CUBIC tissue clearing for whole-organ cell profiling

Transparent organs are obtained, with retained fluorescent protein signals, upon clearing by immersion in the appropriate CUBIC reagent. The positions of all the cells can be determined using the described software.

Katsuhiko Matsumoto
Tomoki T. Mitani
Hiroki R. Ueda
Protocols20 Nov 2019
Nature Protocols

Volume: 14, P: 3506-3537
Green and Sustainable Chemistry in Practice: Development and Industrialization of a Novel Process for Polycarbonate Production from CO₂ without Using Phosgene

Shinsuke Fukuoka
Masahiro Tojo
Kazumi Hasegawa
Reviews16 Jan 2007
Polymer Journal

Volume: 39, P: 91-114
Involvement of H2A variants in DNA damage response of zygotes

Yuan Wang
Dai Tsukioka
Fugaku Aoki
ResearchOpen Access14 May 2024
Cell Death Discovery

Volume: 10, P: 1-10
Genomic profiles of Japanese patients with vulvar squamous cell carcinoma

Erisa Fujii
Mayumi Kobayashi Kato
Hiroshi Yoshida
ResearchOpen Access06 Jun 2024
Scientific Reports

Volume: 14, P: 1-8

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