Nature Search

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.

Seiya Ozono
Yanzhao Zhang
Kenzo Tokunaga
ResearchOpen Access08 Feb 2021
Nature Communications

Volume: 12, P: 1-9
saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern

Vaccines with broad and long-lasting protection against variants of concern are still limited. Here, the authors report a self-amplifying RNA (saRNA) vaccine expressing a membrane-anchored SARS-CoV-2 Spike RBD and show that it elicits broad, durable and protective immunity in small animal models and NHPs.

Mai Komori
Takuto Nogimori
Wataru Akahata
ResearchOpen Access19 May 2023
Nature Communications

Volume: 14, P: 1-14
Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

Tissue clearing has revolutionised histology, but limited penetration of antibodies and stains into thick tissue segments is still a bottleneck. Here, the authors characterise optically cleared tissue as an electrolyte gel and apply this knowledge to stain the entirety of thick tissue samples.

Etsuo A. Susaki
Chika Shimizu
Hiroki R. Ueda
ResearchOpen Access27 Apr 2020
Nature Communications

Volume: 11, P: 1-22
The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

APOBEC3 (A3) proteins are cytidine deaminases that can restrict retroviral replication by causing hypermutation of the viral genome. The HIV-1 protein Vif counteracts the action of A3s by promoting their degradation. Now the crystal structure of A3C and homology models for A3F and A3DE, together with mutagenesis analyses, allow the identification of their interaction interface with Vif, which is different from a previously implicated region in A3G.

Shingo Kitamura
Hirotaka Ode
Yasumasa Iwatani
Research23 Sept 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1005-1010
Population-based nanopore sequencing of the HIV-1 pangenome to identify drug resistance mutations

Hirotaka Ode
Masakazu Matsuda
Yasumasa Iwatani
ResearchOpen Access27 May 2024
Scientific Reports

Volume: 14, P: 1-11
Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients

Mayumi Imahashi
Hirotaka Ode
Yasumasa Iwatani
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-10
Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia

Michiko Nemoto
Hiroyoshi Hattori
Yasumasa Iwatani
ResearchOpen Access03 May 2018
Scientific Reports

Volume: 8, P: 1-13
Arginine insertion and loss of N-linked glycosylation site in HIV-1 envelope V3 region confer CXCR4-tropism

Kiyoto Tsuchiya
Hirotaka Ode
Hiroyuki Gatanaga
ResearchOpen Access08 Aug 2013
Scientific Reports

Volume: 3, P: 1-8

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