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Showing 1–10 of 10 results
Advanced filters: Author: Hiten D. Madhani Clear advanced filters

  • Here, the authors show that anchoring of the PRC2 complex to its own sites requires nuclear condensation of Ccc1, a H3K27me3 reader in the yeast Cryptococcus neoformans, suggesting a functional role for condensates in ensuring heterochromatin fidelity.

    • Sujin Lee
    • Stephen Abini-Agbomson
    • Hiten D. Madhani
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 891-901

  • Identification and analysis of mutator strains in the human fungal pathogen Cryptococcus neoformans show that natural loss of RNA interference triggers massive accumulation of Cnl1 retroelements at subtelomeric regions.

    • Manning Y. Huang
    • Hiten D. Madhani
    News & Views
    Nature Microbiology
    Volume: 7, P: 1108-1109

  • To increase the range and precision of genetic interaction studies in Saccharomyces cerevisiae, a collection of hypomorphic alleles of essential yeast genes and a highly sensitive flow cytometry–based growth competition assay are presented. Also in this issue, Yan et al. present a similar strain collection, tagged with unique bar-code identifiers, and use this collection in pooled chemical genetic screens.

    • David K Breslow
    • Dale M Cameron
    • Jonathan S Weissman
    Research
    Nature Methods
    Volume: 5, P: 711-718

  • Host cell cholesterol is often exploited by pathogens for entry and egress. Two new studies elucidate a new interferon-inducible mechanism by which cells limit plasma membrane cholesterol to promote antibacterial defense.

    • Eric V. Dang
    • Hiten D. Madhani
    • Russell E. Vance
    News & Views
    Nature Immunology
    Volume: 21, P: 716-717

  • Microsporidia are intracellular parasitic fungi that infect diverse animal hosts including humans. Here, Desjardins et al.present genomic and transcriptomic data for two microsporidia that infect disease-transmitting mosquitoes, highlighting differences in potential host interplay mechanisms.

    • Christopher A. Desjardins
    • Neil D. Sanscrainte
    • Christina A Cuomo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • The assembly and maintenance of heterochromatin are carried out by distinct mechanisms that include factors that bind nascent transcripts to recruit chromatin-modifying enzymes. The resulting post-translational modifications on heterochromatic histones contribute to the regulation of development by restricting lineage-specific gene expression.

    • Robin C. Allshire
    • Hiten D. Madhani
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 229-244

  • The Schizosaccharomyces pombe HP1 protein, Swi6, is shown to exist in an auto-inhibited state when unbound to chromatin, switching to a spreading-competent state upon binding to the HK9 methyl mark; disrupting this switch affects heterochromatin assembly and gene silencing.

    • Daniele Canzio
    • Maofu Liao
    • Geeta J. Narlikar
    Research
    Nature
    Volume: 496, P: 377-381