Nature Search

Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein

Kazuko Haga
Tatsuya Haga
Michio Ui
Research22 Aug 1985
Nature

Volume: 316, P: 731-733
Gα_i and Gα_o are target proteins of reactive oxygen species

Motohiro Nishida
Yoshiko Maruyama
Hitoshi Kurose
Research23 Nov 2000
Nature

Volume: 408, P: 492-495
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

The clearance of apoptotic cells by macrophages is important for tissue homoeostasis. Here Nakaya et al. reveal a role for GRK6 in the regulation of apoptotic engulfment and show that GRK6 deficiency in mice leads to autoimmune disease and iron accumulation in the spleen.

Michio Nakaya
Mitsuru Tajima
Hitoshi Kurose
ResearchOpen Access26 Feb 2013
Nature Communications

Volume: 4, P: 1-11
Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

Alteration of circadian rhythms is often observed in patients with chronic kidney disease (CKD). Here, the authors show that CKD-induced dysfunction of the circadian clock increases the expression of G protein-coupled receptor 68 in circulating monocytes and that their cardiac infiltration exacerbates inflammation and fibrosis of heart.

Yuya Yoshida
Naoya Matsunaga
Shigehiro Ohdo
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-17
Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Chronic morphine use can lead to tolerance and AC superactivation. This paper identifies a molecular mechanism by which V1bR signaling promotes this process, providing a potential approach to enhance morphine analgesia without increasing tolerance.

Taka-aki Koshimizu
Kenji Honda
Yukio Takano
Research30 Apr 2018
Nature Neuroscience

Volume: 21, P: 820-833
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Hydrogen sulfide anion reacts with cellular electrophiles, including 8-nitro-cGMP, and sulfhydration products inhibit S-guanylation–dependent H-Ras activation in cardiac inflammatory injury models.

Motohiro Nishida
Tomohiro Sawa
Takaaki Akaike
Research01 Jul 2012
Nature Chemical Biology

Volume: 8, P: 714-724
SREBPs suppress IRS-2-mediated insulin signalling in the liver

Tomohiro Ide
Hitoshi Shimano
Nobuhiro Yamada
Research14 Mar 2004
Nature Cell Biology

Volume: 6, P: 351-357
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction

Akiomi Nagasaka
Chihiro Mogi
Hitoshi Kurose
ResearchOpen Access10 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells

Enkhzol Malchinkhuu
Koichi Sato
Fumikazu Okajima
Research20 Jun 2005
Oncogene

Volume: 24, P: 6676-6688
Gα_12/13 signaling in metabolic diseases

Yoon Mee Yang
Da-Sol Kuen
Sang Geon Kim
ReviewsOpen Access23 Jun 2020
Experimental & Molecular Medicine

Volume: 52, P: 896-910

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