A structural analysis of the apoptosis-inducing protein BAX in complex with a peptide derived from its activator BIM reveals an unforeseen interaction site that does not involve the classic hydrophobic groove reported for inhibitors of apoptosis. This identification of BAX's activation site provides mechanistic insights into a cell's demise.
- Evripidis Gavathiotis
- Motoshi Suzuki
- Loren D. Walensky
