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Showing 1–6 of 6 results
Advanced filters: Author: Holger Winkels Clear advanced filters

  • Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.

    • Michael Lacy
    • Christina Bürger
    • Esther Lutgens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • In inflammation, some regulatory T (Treg) cells lose FoxP3 expression and become exTreg cells. Ley and colleagues mapped mouse Treg and exTreg cell transcriptomes to a human peripheral blood mononuclear cell single-cell RNA-sequencing dataset with surface markers (CITE-seq) and identify human exTreg cells as cytotoxic CD4+ T cells.

    • Antoine Freuchet
    • Payel Roy
    • Klaus Ley
    Research
    Nature Immunology
    Volume: 24, P: 1748-1761

  • Dörnte et al. analyze whether T cell memory towards the B.1.1.529 spike protein of SARS-CoV-2 is retained in individuals vaccinated against the original Wuhan strain of SARS-CoV-2. CD4 and CD8 responses are slightly reduced compared to responses to the original spike protein.

    • Charlyn Dörnte
    • Verena Traska
    • Marc Schuster
    ResearchOpen Access
    Communications Medicine
    Volume: 2, P: 1-6

  • Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis in mice.

    • Dennis Wolf
    • Nathaly Anto-Michel
    • Andreas Zirlik
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Accumulating evidence supports the critical role of T cells as drivers and modifiers of atherosclerosis. In this Review, Ley and colleagues describe the latest advances in our understanding of the role of T cell subsets in atherosclerosis, discuss the process of T cell homing to atherosclerotic plaques and highlight potential T cell-related therapies for atherosclerosis.

    • Ryosuke Saigusa
    • Holger Winkels
    • Klaus Ley
    Reviews
    Nature Reviews Cardiology
    Volume: 17, P: 387-401