Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear exosome targeting complex and occurs independently of the nuclear m6A reader YTHDC1.
- Guifeng Wei
- Heather Coker
- Neil Brockdorff
