Biophotoelectrocatalysis-driven oxyfunctionalization of C–H bonds is often hampered by unselective photoelectrochemical water oxidation and the generation of peroxygenase-deactivating hydroxyl radicals. Here a bicarbonate redox mediator redirects water oxidation from a direct pathway to an indirect pathway for H2O2 formation that avoids radical stress, enabling robust oxygenative biosynthesis.
- Chang Hyun Kim
- Chung Hyeon Lee
- Chan Beum Park
