Although small molecules that act on cannabinoid CB1 receptor are known to modulate cocaine seeking behavior in rodents, the role of type 2 cannabinoid receptor (CB2R) in drug of abuse–related behavior is less clear. Here, Xi and colleagues demonstrate that a selective CB2R antagonist inhibits cocaine self-administration in mice by acting through central CB2Rs in the nucleus accumbens.
- Zheng-Xiong Xi
- Xiao-Qing Peng
- Eliot L Gardner
