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Advanced filters: Author: Hong-Ting Prekop Clear advanced filters

Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Many diseases are caused by single-nucleotide polymorphisms. Here, the authors present CRISPR base editors that use the base excision machinery for single-base transversions.

Liwei Chen
Jung Eun Park
Wei Leong Chew
ResearchOpen Access02 Mar 2021
Nature Communications

Volume: 12, P: 1-7
Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

The development and function of thalamic interneurons is only partially understood. Here the authors describe the unexpected mesencephalic origin of the GABAergic interneurons of the visual thalamus that provide both phasic and tonic modulation of thalamic relay neuron excitability.

Polona Jager
Zhiwen Ye
Alessio Delogu
ResearchOpen Access08 Dec 2016
Nature Communications

Volume: 7, P: 1-14

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Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

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