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Showing 1–50 of 77 results

Advanced filters: Author: Hong-li Li Clear advanced filters

The antibody–drug conjugate SHR-A1904 for targeting CLDN18.2 in advanced gastric or gastroesophageal junction cancer: a phase 1 trial

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Dan-Yun Ruan
Hao-Xiang Wu
Rui-Hua Xu
Research16 Jul 2025
Nature Medicine

Volume: 31, P: 3037-3046
A network of velocity-coherent filaments formed by supersonic turbulence in a very-high-velocity H i cloud

High-resolution FAST observations of a very-high-velocity cloud in the warm neutral medium reveal a network of hierarchical filaments formed by shock compression. These findings suggest a viable mechanism for early structure formation in the interstellar medium.

Xunchuan Liu
Tie Liu
Zhiqiang Shen
Research16 Jul 2025
Nature Astronomy

Volume: 9, P: 1366-1374
PopPK modeling supports BW band dosing of lacosamide for pediatric epilepsy

Yue Li
Hong-Li Guo
Feng Chen
ResearchOpen Access28 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-11
Evaluating and prioritizing interdependent strategies for construction land reduction in China with interdependent sustainability criteria: an integrated multi-criteria decision-making approach

Jia-He Zhou
Chao-Yue Yu
Hong-Li Lin
ResearchOpen Access15 May 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-18
Skillful seasonal predictions of continental East-Asian summer rainfall by integrating its spatio-temporal evolution

This study proposes a physical-statistical model that significantly improves seasonal predictions of the spatiotemporal evolution of East-Asian rainfall anomalies, outperforming current state-of-the-art dynamical models in forecasting climate disasters.

Jieru Ma
Hong-Li Ren
Lin Wang
ResearchOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1-10
PVN Blockade of p44/42 MAPK Pathway Attenuates Salt-induced Hypertension through Modulating Neurotransmitters and Attenuating Oxidative Stress

Hong-Li Gao
Xiao-Jing Yu
Yu-Ming Kang
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Identification of new susceptibility loci for IgA nephropathy in Han Chinese

IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk.

Ming Li
Jia-Nee Foo
Jian-Jun Liu
ResearchOpen Access01 Jun 2015
Nature Communications

Volume: 6, P: 1-9
Coupled catalytic states and the role of metal coordination in Cas9

Cas9 is a powerful genome-manipulation enzyme, although how its catalytic activity is controlled is not completely solved. Now, cryo-electron microscopy structures of Acidothermus cellulolyticus Cas9 provide atomic-level insights into its activation involving DNA binding, conformational changes and the formation of its two active sites.

Anuska Das
Jay Rai
Hong Li
ResearchOpen Access02 Oct 2023
Nature Catalysis

Volume: 6, P: 969-977
Virus detection via programmable Type III-A CRISPR-Cas systems

CRISPR-Cas based virus detection assays can be both rapid and sensitive. Here the authors use a Type III-A CRISPR-Cas system to detect SARS-CoV-2.

Sagar Sridhara
Hemant N. Goswami
Hong Li
ResearchOpen Access27 Sept 2021
Nature Communications

Volume: 12, P: 1-10
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

Chen Wu
Zhaoming Wang
Stephen J Chanock
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 1001-1006
Evolution of schooling drives changes in neuroanatomy and motion characteristics across predation contexts in guppies

Corral-Lopez et al. use guppies as a model system for the evolution of collective motion. They show that guppies artificially selected for schooling remain highly coordinated across predation contexts and show key changes in brain morphology that likely increase the efficiency of sensory information relay.

Alberto Corral-Lopez
Alexander Kotrschal
Niclas Kolm
ResearchOpen Access27 Sept 2023
Nature Communications

Volume: 14, P: 1-15
A combination mode of the annual cycle and the El Niño/Southern Oscillation

The development and termination of El Niño events seem to be coupled with the seasonal cycle. Statistical analyses suggest that this link reflects the presence of a combination climate mode with periods of 10 and 15 months.

Malte F. Stuecker
Axel Timmermann
Hong-Li Ren
Research26 May 2013
Nature Geoscience

Volume: 6, P: 540-544
LAMP, a new imaging assay of gap junctional communication unveils that Ca²⁺ influx inhibits cell coupling

Kenneth Dakin
YuRui Zhao
Wen-Hong Li
Research21 Dec 2004
Nature Methods

Volume: 2, P: 55-62
The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9

Acidothermus cellulolyticus CRISPR-Cas9 (AceCas9) is a Type II-C enzyme that cleaves DNA in a Protospacer Adjacent Motif (PAM) methylation sensitive fashion. Biochemical analysis and crystal structures of AceCas9 in complex with sgRNA and DNA bearing the correct and incorrect PAM offer insight into the structural basis for the recognition of PAM and its methylation.

Anuska Das
Travis H. Hand
Hong Li
ResearchOpen Access11 Dec 2020
Nature Communications

Volume: 11, P: 1-11
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus

Yan Zhang
Xiao-Jing Yu
Yu-Ming Kang
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Nutrient enrichment alters impacts of Hydrocotyle vulgaris invasion on native plant communities

Lin Liu
Han Quan
Hong-Li Li
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

Wei Wu
Ya-li Zheng
Shao-hua Hu
ResearchOpen Access11 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA

The box H/ACA pseudouridine synthase complex guides modification of small nucleolar and Cajal body ribonucleoproteins (sno/scaRNAs), which are essential for maturation of the ribosome and spliceosome. The structure of a functional H/ACA complex containing L7Ae, Nop1 and Cbf5 proteins bound to the substrate and guide RNAs and with a catalytically rearranged substrate in the active site is now presented.

Bo Liang
Jing Zhou
Hong Li
Research28 May 2009
Nature Structural & Molecular Biology

Volume: 16, P: 740-746
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Cell-cell coupling via gap junctions has been extensively studied in vitro and in heterologous systems, but in vivo studies are still few. A new class of photoactivatable bioconjugates is now used to monitor gap junctional coupling in living Caenorhabditis elegans.

Yan-Ming Guo
Shiuhwei Chen
Wen-hong Li
Research01 Aug 2008
Nature Methods

Volume: 5, P: 835-841
Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus

Hong-Li Gao
Xiao-Jing Yu
Yu-Ming Kang
ResearchOpen Access25 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Efficacy of repetitive transcranial magnetic stimulation with quetiapine in treating bipolar II depression: a randomized, double-blinded, control study

Shao-hua Hu
Jian-bo Lai
Yi Xu
ResearchOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1-7
Sediment Type Affects Competition between a Native and an Exotic Species in Coastal China

Hong-Li Li
Yong-Yang Wang
Ming-Xiang Zhang
ResearchOpen Access23 Oct 2014
Scientific Reports

Volume: 4, P: 1-5
Light Management in Flexible Glass by Wood Cellulose Coating

Zhi-Qiang Fang
Hong-Li Zhu
Liang-Bing Hu
ResearchOpen Access28 Jul 2014
Scientific Reports

Volume: 4, P: 1-7
Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation

Hong-li Liu
Yan Chen
Jian-feng Zhou
Research01 May 2005
Acta Pharmacologica Sinica

Volume: 26, P: 603-609
Pd/C Synthesized with Citric Acid: An Efficient Catalyst for Hydrogen Generation from Formic Acid/Sodium Formate

Zhi-Li Wang
Jun-Min Yan
Qing Jiang
ResearchOpen Access23 Aug 2012
Scientific Reports

Volume: 2, P: 1-6
The predictive value of soluble osteoclast-associated receptor for the prognosis of acute coronary syndrome

Rong Wang
Jing Wang
Qing Zhang
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-5
Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

Biomarker strategies are increasingly being applied in drug development to address the challenges posed by heterogeneity in the underlying mechanisms of disease processes and inter-patient variability in drug responses. With the aim of enhancing understanding of the regulatory significance of such biomarker data by regulators and sponsors, the US FDA initiated a programme in 2004 to allow sponsors to submit exploratory data voluntarily, without immediate regulatory impact. This article discusses a selection of case studies from the first 5 years of this programme, highlighting lessons learned.

Federico M. Goodsaid
Shashi Amur
Issam Zineh
Reviews01 Jun 2010
Nature Reviews Drug Discovery

Volume: 9, P: 435-445
Author Correction: El Niño–Southern Oscillation complexity

Axel Timmermann
Soon-Il An
Xuebin Zhang
Amendments and Corrections20 Feb 2019
Nature

Volume: 567, P: E3
Self-templated synthesis of novel carbon nanoarchitectures for efficient electrocatalysis

Xi-Lin Wu
Tao Wen
Markus Mezger
ResearchOpen Access15 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
Phenotype-dependent alteration of pathways and networks reveals a pure synergistic mechanism for compounds treating mouse cerebral ischemia

Peng-qian Wang
Bing Li
Zhong Wang
Research11 May 2015
Acta Pharmacologica Sinica

Volume: 36, P: 734-747
Regulating expressions of cyclin D1, pRb, and anti-cancer effects of deguelin on human Burkitt's lymphoma Daudi cells in vitro

Hong-li Liu
Yan Chen
Jing He
Research01 Jul 2005
Acta Pharmacologica Sinica

Volume: 26, P: 873-880
Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis

Chao Tang
An-hua Wu
Yun-jie Wang
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1116-1122
Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma

Ke Wang
Chun-tao Liu
Fu-qiang Wen
Research20 Dec 2010
Acta Pharmacologica Sinica

Volume: 32, P: 126-132
Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro

Hong-li Liu
Yan Chen
Jian-feng Zhou
Research01 Oct 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1265-1273
Impact of a WeChat-based intervention on nurses knowledge and practice in peripheral venous catheter insertion

Ai-zhen Hu
Xiao-ying Yin
Lin Liu
ResearchOpen Access25 May 2025
Scientific Reports

Volume: 15, P: 1-8
Infrared-LAMP: two-photon uncaging and imaging of gap junctional communication in three dimensions

Kenneth Dakin
Wen-hong Li
Correspondence01 Dec 2006
Nature Methods

Volume: 3, P: 959
Crafting new cages

A new caging group based on the nitrodibenzofuran chromophore has been developed with improved photochemical properties for both ultraviolet and two-photon photolysis applications, providing a new tool for the rapid and efficient release of calcium ions for biological studies.

Wen-Hong Li
News & Views01 Jan 2006
Nature Methods

Volume: 3, P: 13-15
Individualized atomoxetine response and tolerability in children with ADHD receiving different dosage regimens: the need for CYP2D6 genotyping and therapeutic drug monitoring to dance together

Hong-Li Guo
Dan-Dan Wu
Feng Chen
ResearchOpen Access19 Mar 2024
Translational Psychiatry

Volume: 14, P: 1-11
Future climate-driven escalation of Southeastern Siberia wildfires revealed by deep learning

Ke Gui
Xutao Zhang
Xiaoye Zhang
ResearchOpen Access29 Oct 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1-10
Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao
Bin-shu Weng
Ya-ping Ye
Amendments and CorrectionsOpen Access02 Nov 2022
Cell Death & Disease

Volume: 13, P: 1
Structural basis of tolvaptan binding to the vasopressin V₂ receptor

Hong-li Liu
Hai-yang Zhong
Dong Guo
Research20 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2441-2449
RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao
Bin-shu Weng
Ya-ping Ye
ResearchOpen Access24 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-13
Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice

Yu-Nu Ma
Chao-Juan Yang
Tian-Mei Si
ResearchOpen Access22 Nov 2024
Molecular Psychiatry

Volume: 30, P: 2407-2426
Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

Hong-xia Guo
Dai-hua Liu
Hong-li Peng
Research05 Nov 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1505-1512
Effects of glucose metabolism during in vitro maturation on cytoplasmic maturation of mouse oocytes

Hong-Li Xie
Yan-Bo Wang
Jing-He Tan
ResearchOpen Access09 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Identification and characterization of novel serum microRNA candidates from deep sequencing in cervical cancer patients

Li Juan
Hong-li Tong
Ya-ping Tian
ResearchOpen Access03 Sept 2014
Scientific Reports

Volume: 4, P: 1-9
The effects of nitrogen fertilization on N₂O emissions from a rubber plantation

Wen-Jun Zhou
Hong-li Ji
Xun-Hua Zheng
ResearchOpen Access21 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Dorsal CA3 overactivation mediates witnessing stress-induced recognition memory deficits in adolescent male mice

Xiao Liu
Rui Liu
Tian-Mei Si
Research19 Mar 2024
Neuropsychopharmacology

Volume: 49, P: 1666-1677
Correlations between genetic, epigenetic and phenotypic variation of an introduced clonal herb

Mo-Zhu Wang
Hong-Li Li
Fei-Hai Yu
Research20 Aug 2019
Heredity

Volume: 124, P: 146-155
El Niño–Southern Oscillation complexity

Our current understanding of the spatio-temporal complexity of the El Niño–Southern Oscillation phenomenon is reviewed and a unifying framework that identifies the key factors for this complexity is proposed.

Axel Timmermann
Soon-Il An
Xuebin Zhang
Reviews25 Jul 2018
Nature

Volume: 559, P: 535-545

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