Wang et al. develop an LC/MS based screening method to separate and quantify aminobutyric acids isoforms. Applying it to osteoporosis clinical studies, their method yields important correlations with bone mineral density and osteoporotic fracture and highlight the role of γ-aminobutyric acid and β-aminoisobutyric acid as biomarkers for osteoporosis.
- Zhiying Wang
- Liangqiao Bian
- Marco Brotto
