The role of the histonemethyltransferase KMT2D mutations in head and neck squamous cell carcinoma (HNSCC) remains to be explored. Here, the authors show that KMT2D deficiency in HNSCC impairs the Fanconi Anemia (FA)/BRCA pathway under glycolytic inhibition, rendering HNSCC hypersensitive to DNA crosslinking agents and PARP inhibitors.
- Wei Liu
- Hongchao Cao
- Cun-Yu Wang
