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Showing 1–3 of 3 results
Advanced filters: Author: Hongjae Sunwoo Clear advanced filters

  • The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilitates Xist RNA spreading between Xi compartments.

    • Chen-Yu Wang
    • David Colognori
    • Jeannie T. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The formation of subnuclear domains, such as the paraspeckles where hyperdited mRNAs are stored, is not well understood. The transcription of the paraspeckle non-coding RNA MEN ɛ/β initiates the recruitment of other components to assemble this nuclear body.

    • Yuntao S. Mao
    • Hongjae Sunwoo
    • David L. Spector
    Research
    Nature Cell Biology
    Volume: 13, P: 95-101

  • LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.

    • Jordan P. Lewandowski
    • James C. Lee
    • John L. Rinn
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13