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Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy

A biodegradable MgSO₄-reinforced poly (l-lactide-co-ε-caprolactone) cerebral stent was prepared by 3D-printing technique, providing efficient neuroprotection effects on ischemic brain tissues through sequential release of Mg ions.

Hongkang Zhang
Yang Zhang
Yufeng Zheng
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-22
A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

Zhao and colleagues find that neuropathic pain is accompanied by an increase in the expression of an antisense long noncoding RNA (lncRNA) that downregulates Kcna2 currents and increases excitability in rat dorsal root ganglion neurons. Preventing the expression of the so-called Kcna2 antisense RNA mitigates neuropathic pain symptoms.

Xiuli Zhao
Zongxiang Tang
Yuan-Xiang Tao
Research23 Jun 2013
Nature Neuroscience

Volume: 16, P: 1024-1031
Metabotropic GABA signalling modulates longevity in C. elegans

TheC. elegans nervous system influences organismal lifespan but mechanistic details are poorly understood. Here, Chun et al. show that the neurotransmitter GABA regulates worm lifespan by acting on GABA_Breceptors in motor neurons, which activate the transcription factor DAF-16 in the intestine.

Lei Chun
Jianke Gong
Jianfeng Liu
ResearchOpen Access05 Nov 2015
Nature Communications

Volume: 6, P: 1-10
Antibody targeting of E3 ubiquitin ligases for receptor degradation

Membrane-bound E3 ubiquitin ligases RNF43 and ZNRF3 are overexpressed in colorectal cancer, and can be repurposed using proteolysis-targeting antibodies (PROTABs) to selectively degrade cell-surface receptors in tumours.

Hadir Marei
Wen-Ting K. Tsai
Felipe de Sousa e Melo
ResearchOpen Access21 Sept 2022
Nature

Volume: 610, P: 182-189
A stress-tolerant strain Rhodococcus sp. WH103 was isolated and co-immobilized to more efficiently degrade phenazine-1-carboxylic acid

Hui Wang
Xiang Wang
Shubao Hu
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

AhYoung, Eckard et al. show that the expression of Neutrophil Serine Protease 4 (NSP4) during the early stages of mast cell development regulates the levels of histamine and serotonin in mast cell granules. This study reveals an important physiological function of NSP4 in mast cell-mediated vascular leakage in mice, establishing NSP4 as a potential therapeutic target for mast cell-dependent immune disorders.

Andrew P. AhYoung
Sterling C. Eckard
Menno van Lookeren Campagne
ResearchOpen Access19 Nov 2020
Communications Biology

Volume: 3, P: 1-13
Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) Type IV promoter by interferon regulatory factors 1 and 2

Hongkang Xi
Donna D Eason
George Blanck
Research21 Oct 1999
Oncogene

Volume: 18, P: 5889-5903

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Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

Metabotropic GABA signalling modulates longevity in C. elegans

Antibody targeting of E3 ubiquitin ligases for receptor degradation

A stress-tolerant strain Rhodococcus sp. WH103 was isolated and co-immobilized to more efficiently degrade phenazine-1-carboxylic acid

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) Type IV promoter by interferon regulatory factors 1 and 2

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Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

Metabotropic GABA signalling modulates longevity in C. elegans

Antibody targeting of E3 ubiquitin ligases for receptor degradation

A stress-tolerant strain Rhodococcus sp. WH103 was isolated and co-immobilized to more efficiently degrade phenazine-1-carboxylic acid

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage

Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) Type IV promoter by interferon regulatory factors 1 and 2

Search

Quick links