Abnormal amyloid beta (Aβ) aggregation is central to Alzheimer’s disease pathology, yet efficient screening for inhibitors remains challenging. Here, the authors employ structure-based virtual screening of a traditional Chinese medicine library, identifying forsythoside A as a potent inhibitor that reduces Aβ40 aggregation and alleviates toxicity in Caenorhabditis elegans.
- Si-Cong Bai
- Ye-Cheng Wang
- Gao Li
