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Showing 1–2 of 2 results
Advanced filters: Author: Howard B. Seim III Clear advanced filters
  • The growth factor NELL-1 induces bone formation during development, but its role in osteoporosis is unknown. This study shows that NELL-1 binding to integrin ß1 induces Wnt/ß-catenin signalling in the bone and restores bone mineral density in osteoporotic mice and sheep, suggesting the therapeutic potential of NELL-1 for the treatment of bone loss.

    • Aaron W. James
    • Jia Shen
    • Chia Soo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14