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Showing 1–3 of 3 results
Advanced filters: Author: Hsiau-Wei Lee Clear advanced filters

  • Naturally occurring peptides with high membrane permeability often have backbone ester bonds. Here, the authors investigated the effect of an amide-to-ester substitution on membrane permeability of peptides and found the substitution is useful for improving membrane permeability of cyclic peptides.

    • Yuki Hosono
    • Satoshi Uchida
    • Shinsuke Sando
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The MuvB complex, which regulates cell cycle dependent gene expression, binds promoter cell cycle genes homology region (CHR) elements. Here the authors solve the structure of LIN54, a component of MuvB, bound to DNA and use it to explain the recognition of a CHR sequence.

    • Aimee H. Marceau
    • Jessica G. Felthousen
    • Seth M. Rubin
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The mammalian circadian cycle is determined by sequential activation of clock target-gene expression by CLOCK–BMAL and subsequent repression by CRY. Biochemical and NMR data now show that Cry1 competes with coactivators for binding to the BMAL1 transcriptional-activation domain to regulate circadian cycling.

    • Haiyan Xu
    • Chelsea L Gustafson
    • Carrie L Partch
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 476-484