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Showing 1–2 of 2 results
Advanced filters: Author: Hsin-Chin Lai Clear advanced filters

  • Stabilization of DNA quadruplex structures (G4) is lethal for cells with a compromised DNA repair pathway. Here, the authors show that CX-5461, a small molecule in clinical trials as RNA polymerase inhibitor, has G4-stablization properties and can be repurposed to target DNA repair-defective cancers cells.

    • Hong Xu
    • Marco Di Antonio
    • Samuel Aparicio
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • Cheng-Lung Ku and colleagues report that anti-interferon (IFN)-γ autoantibodies in patients with disseminated mycobacterial infections recognize the C-terminus of IFN-γ, and suggest that autoantibodies may arise by molecular mimicry. The authors propose a therapeutic strategy to treat patients using a modified IFN-γ that escapes neutralization by autoantibodies.

    • Chia-Hao Lin
    • Chih-Yu Chi
    • Cheng-Lung Ku
    Research
    Nature Medicine
    Volume: 22, P: 994-1001