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Showing 1–10 of 10 results
Advanced filters: Author: Hubertus Kohler Clear advanced filters
  • Here, the authors show that KDM2A regulates cell cycle progression, modulation of H3K36me2 and H3K27me3 chromatin states and gene repression which are critical for survival of differentiating spermatogonia. KDM2A regulates progression through meiosis as well.

    • Michael T. Bocker
    • Grigorios Fanourgakis
    • Thomas B. Nicholson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • The authors discovered a far distant genomic region containing multiple clusters of regulatory elements that drive coordinated Hoxa expression across chromatin topologically associating domains in cranial neural crest, and are required for patterning of facial structures.

    • Sandra Kessler
    • Maryline Minoux
    • Filippo M. Rijli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22
  • The transcriptional effect of an enhancer depends on its contact probabilities with the promoter through a nonlinear relationship, and enhancer strength determines absolute transcription levels as well as the sensitivity of a promoter to CTCF-mediated transcriptional insulation.

    • Jessica Zuin
    • Gregory Roth
    • Luca Giorgetti
    ResearchOpen Access
    Nature
    Volume: 604, P: 571-577
  • In patient-derived xenograft models of breast cancer in mice, an increase in stress hormones during progression or treatment with their synthetic derivatives activates the glucocorticoid receptor, and results in increased metastatic colonization and reduced survival.

    • Milan M. S. Obradović
    • Baptiste Hamelin
    • Mohamed Bentires-Alj
    Research
    Nature
    Volume: 567, P: 540-544
  • PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, the PIK3CAH1047R mutation is shown to induce multipotent stem-like cells and mammary tumours with different levels of malignancy depending on the cell of origin.

    • Shany Koren
    • Linsey Reavie
    • Mohamed Bentires-Alj
    Research
    Nature
    Volume: 525, P: 114-118
  • Using several lines of retinal cell type–specific GENSET BAC transgenic GFP mice, the authors segregated these retinal cell types then subjected them to transcriptome microarray analysis to provide a transcriptional 'barcode' of retinal cell identity.

    • Sandra Siegert
    • Erik Cabuy
    • Botond Roska
    Research
    Nature Neuroscience
    Volume: 15, P: 487-495
  • The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, including the maintenance of high levels of Oct4 and Nanog and ensuring the proper timing of meiosis through the suppression of retinoic acid signalling in female PGCs.

    • Shihori Yokobayashi
    • Ching-Yeu Liang
    • Antoine H. F. M. Peters
    Research
    Nature
    Volume: 495, P: 236-240