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Showing 1–11 of 11 results
Advanced filters: Author: Hugh J. Willison Clear advanced filters
  • John W. 'Jack' Griffin (1942–2011) was the launch Editor-in-Chief ofNature Clinical Practice Neurology, and continued to serve on the Advisory Board after the journal was rebranded as Nature Reviews Neurologyin 2009. In this Essay, the authors pay tribute to Jack, highlighting his seminal contributions to the field of inflammatory neuropathies, and reviewing recent progress in this area, including the emergence of the node of Ranvier as a site of intensive investigation.

    • Eva L. Feldman
    • Richard A. C. Hughes
    • Hugh J. Willison
    Comments & Opinion
    Nature Reviews Neurology
    Volume: 11, P: 646-650
  • 2016 has marked 100 years since the landmark description of what we now know as Guillain–Barré syndrome (GBS). Goodfellow and Willison chart the great progress we have made in understanding the pathogenesis of GBS, and developing established and emerging therapies.

    • John A. Goodfellow
    • Hugh J. Willison
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 723-731
  • Autoantibodies against nerve glycosphingolipid antigens have been shown to have a central role in Guillain–Barré syndrome pathogenesis. Until recently, research has focused on antibody reactivity to highly purified single species of gangliosides, but new findings highlight the importance of analyzing antibody reactivity to ganglioside complexes.

    • Hugh J Willison
    Reviews
    Nature Clinical Practice Neurology
    Volume: 1, P: 2-3
  • John W. Griffin, internationally renowned expert on peripheral nerve disorders, founding Director of the Johns Hopkins Brain Science Institute and launch Editor-in-Chief of Nature Reviews Neurology, died on 16th April 2011. He will be remembered for his leadership in academic medicine, strong advocacy for young neurologists, and many original research contributions.

    • Ahmet Höke
    • Hugh J. Willison
    News & Views
    Nature Reviews Neurology
    Volume: 7, P: 361-362
  • Adenovirus type 37 (Ad37) causes epidemic keratoconjunctivitis, a highly contagious disease for which there is no specific antiviral therapy. The receptor for Ad37 infection was previously unidentified, but known to contain sialic acid. Nilsson et al. report here that Ad37 binds to the GD1a glycan motif of the GD1a ganglioside. This finding may facilitate the development of antiviral agents targeting Ad37-associated disease.

    • Emma C Nilsson
    • Rickard J Storm
    • Niklas Arnberg
    Research
    Nature Medicine
    Volume: 17, P: 105-109
  • Biomarkers are generally used as diagnostic and prognostic tools in clinical practice, but are not yet available for neuropathies. Studies now suggest that neural protein levels in serum and cerebrospinal fluid reflect axonal damage and predict poor outcome in patients with immune-mediated neuropathy, although validation studies are needed to define their clinical relevance.

    • Bart C. Jacobs
    • Hugh J. Willison
    News & Views
    Nature Reviews Neurology
    Volume: 5, P: 584-585
  • Various clinical scores are available to assess the outcome of chronic inflammatory demyelinating polyneuropathy (CIDP), but these existing scales have some major limitations. A novel, simple scoring system—the CIDP disease activity status—incorporates the concept of disease activity as a feature that informs the long-term outcome in CIDP patients.

    • Hans-Peter Hartung
    • Helmar C. Lehmann
    • Hugh J. Willison
    News & Views
    Nature Reviews Neurology
    Volume: 7, P: 250-251
  • In this Perspective, the authors discuss the importance of preventing zoonotic spillover to prevent pandemics. They highlight mechanisms by which environmental changes can enable spillover, identify ecological interventions for spillover prevention and suggest policy frameworks through which interventions can be implemented.

    • Raina K. Plowright
    • Aliyu N. Ahmed
    • Annika T. H. Keeley
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • In this Consensus Statement, Leonhard et al. provide a globally applicable guideline for the diagnosis and management of Guillain–Barré syndrome, including information on early recognition of the disease, prediction of clinical course and outcome, and management of complications and sequelae.

    • Sonja E. Leonhard
    • Melissa R. Mandarakas
    • Bart C. Jacobs
    ReviewsOpen Access
    Nature Reviews Neurology
    Volume: 15, P: 671-683