When proteins are secreted from the endoplasmic reticulum (ER) to the Golgi apparatus, they are packaged into vesicles that travel to and fuse with the tubular network at the cis face of the Golgi. But what happens if the ER is a long way from the Golgi? An elegant new study using green fluorescent protein shows that the vesicles fuse to form a vesicular-tubular network, which travels down microtubules to fuse with the cis-Golgi network.
