The authors aimed to identify epigenetic aberrations involving microRNAs (miRNAs) whose genes become hypermethylated in endometrial primary tumors. They found that that miR-137 is hypermethylated and loses expression in human endometrial tumors. Increasing miR-137 expression suppresses endometrial cancer cell growth in vitro and xenograft tumor growth in nude mice, partly because miR-137 targets EZH2, which participates in histone methylation, and LSD1, a histone demethylation enzyme.
- Wei Zhang
- Jo-Hsin Chen
- Yi-Wen Huang
