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Showing 1–4 of 4 results

Advanced filters: Author: Huijue Lyu Clear advanced filters

A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer

POU2AF2 is a co-activator of POU2F3 in normal and neoplastic tuft cells, such as small cell lung cancer. Here, the authors report that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements.

Aileen Szczepanski
Natsumi Tsuboyama
Lu Wang
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Genome-wide detection of enhancer-hijacking events from chromatin interaction data in rearranged genomes

This work presents NeoLoopFinder, a computational method, for identifying chromatin interactions of structurally rearranged genomes. NeoLoopFinder was applied in 50 cancer datasets and identified genes associated with enhancer-hijacking events.

Xiaotao Wang
Jie Xu
Feng Yue
Research03 Jun 2021
Nature Methods

Volume: 18, P: 661-668
Subtype-specific 3D genome alteration in acute myeloid leukaemia

Extensive genomic analyses of the chromatin architecture in acute myeloid leukaemia reveals several characteristics, including subtype-specific distal enhancers and silencers, that may represent new anticancer therapeutic targets.

Jie Xu
Fan Song
Feng Yue
Research26 Oct 2022
Nature

Volume: 611, P: 387-398
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57