Nature Search

Molecular characterization and prognostic implications of KRAS mutations in pancreatic cancer patients: insights from multi-cohort analysis

Yubo Jiang
Gang Mai
Huirong Xu
ResearchOpen Access22 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-11
Structural insights into TSC complex assembly and GAP activity on Rheb

Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.

Huirong Yang
Zishuo Yu
Yanhui Xu
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

DNMT1 is a methyl-transferase involved in maintaining tissue-specific patterns of DNA methylation. Here the authors solve the structure of a DNMT1-USP7 complex and demonstrate the mechanism by which DNMT1 stability is regulated through acetylation by preventing association with the deubiquitinase USP7.

Jingdong Cheng
Huirong Yang
Yanhui Xu
ResearchOpen Access11 May 2015
Nature Communications

Volume: 6, P: 1-11
Superior field performance of waxy corn engineered using CRISPR–Cas9

Gene-edited waxy corn lines have higher yields in field trials than hybrids produced by traditional trait introgression.

Huirong Gao
Mark J. Gadlage
R. Bob Meeley
Research09 Mar 2020
Nature Biotechnology

Volume: 38, P: 579-581
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders

Placenta accreta spectrum (PAS) is a high-risk obstetrical complication associated with significant morbidity and mortality. Here the authors discover a uniquely high prevalence of circulating trophoblasts clusters in PAS and explore their diagnostic potential to augment current diagnostic modalities for the early detection of PAS.

Yalda Afshar
Jiantong Dong
Yazhen Zhu
ResearchOpen Access03 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist

Sustained Mars exploration requires in situ synthesis of vital chemicals such as oxygen. Now a data-driven platform for synthesizing oxygen-producing electrocatalysts from Martian meteorites using robotics and artificial intelligence is developed, allowing automated screening of the optimal catalyst formula. This approach demonstrates materials discovery under challenging circumstances and without human intervention.

Qing Zhu
Yan Huang
Yi Luo
Research13 Nov 2023
Nature Synthesis

Volume: 3, P: 319-328
Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics

The clinical application of magnetic hyperthermia therapy (MHT) is limited by the poor magnetic-to-thermal conversion efficiency of MHT agents. Here, the authors develop encapsulin-produced magnetic iron oxide nanocomposites (eMIONs) with excellent magnetic-heat capability and catalysis-triggered tumor suppression ability to overcome the critical issues of MHT.

Yang Zhang
Xiaoyong Wang
Gang Liu
ResearchOpen Access27 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is involved in the maintenance of DNA methylation, but the regulatory mechanism of this epigenetic regulator is unclear. Here, the authors show that it has a closed conformation and are able to make conclusions about the mechanism of recognition of epigenetic marks.

Jian Fang
Jingdong Cheng
Yanhui Xu
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Hirschsprung’s disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β

Yang Yang
Mengzhen Zhang
Kai Wu
Research24 Apr 2024
Pediatric Research

Volume: 96, P: 942-951
Autoantibody against β₁-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4⁺ T cells by up-regulating AMPK-mediated fatty acid oxidation

Xu Wenli
Wu Ye
Liu Huirong
ResearchOpen Access15 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-13
Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults

Zixuan Fu
Xiaofang Xu
Xiujuan Yang
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-12
Cryo-EM structure of human mTOR complex 2

Xizi Chen
Mengjie Liu
Yanhui Xu
Research22 Mar 2018
Cell Research

Volume: 28, P: 518-528
A modular chemoenzymatic cascade strategy for the structure-customized assembly of ganglioside analogs

Gangliosides are composed of oligosaccharide chains attached to ceramides and are employed as targeted drugs and diagnostic biomarkers, however, their industrially-relevant synthesis remains challenging. Here, the authors develop a modular chemoenzymatic cascade assembly strategy for the customized and large-scale synthesis of ganglioside analogues with various glycan and ceramide epitopes.

Xuefeng Jin
Hanchao Cheng
Guang-Yu Yang
ResearchOpen Access18 Jan 2024
Communications Chemistry

Volume: 7, P: 1-13
KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

KLF4-induced phenotypic switching of vascular smooth muscle cells occurs in atherosclerosis. Now, KLF4 is shown to induce a glycolytic shift involving upregulation of PFKFB3 expression through circular RNA CTDP1 and eukaryotic elongation factor eEF1A2.

Xinhua Zhang
Bin Zheng
Jinkun Wen
ResearchOpen Access05 Dec 2022
Communications Biology

Volume: 5, P: 1-17
Wuschel2 enables highly efficient CRISPR/Cas-targeted genome editing during rapid de novo shoot regeneration in sorghum

Che et al. use Wuschel2-enabled genome transformation to induce somatic embryo formation in sorghum, a grain used in human food. Their approach not only overcomes the genotype-dependent barrier for genetic transformation without the introduction of morphogenic genes, but also increases the frequency of CRISPR/Castargeted genome editing.

Ping Che
Emily Wu
Todd J. Jones
ResearchOpen Access11 Apr 2022
Communications Biology

Volume: 5, P: 1-11
Structure of the human RNA polymerase I elongation complex

Dan Zhao
Weida Liu
Yanhui Xu
ResearchOpen Access20 Oct 2021
Cell Discovery

Volume: 7, P: 1-12
Structural insight into substrate recognition by histone demethylase LSD2/KDM1b

Fei Chen
Huirong Yang
Yanhui Xu
Correspondence29 Jan 2013
Cell Research

Volume: 23, P: 306-309
Increased AT₂R expression is induced by AT₁R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration

Yan Sun
Yang Li
Huirong Liu
ResearchOpen Access08 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-17
Tomato UV-B receptor SlUVR8 mediates plant acclimation to UV-B radiation and enhances fruit chloroplast development via regulating SlGLK2

Huirong Li
Yuxiang Li
Songhu Wang
ResearchOpen Access17 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion

Zhenlu Li
Guangzhi Wang
Xiaofeng Tian
ResearchOpen Access30 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-17
Decreased autophagy induced by β₁-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis

Li Wang
Yang Li
Huirong Liu
ResearchOpen Access14 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-13
Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis

Yan Sun
Suli Zhang
Huirong Liu
ResearchOpen Access01 May 2019
Cell Death & Disease

Volume: 10, P: 1-12
Biased activation of β₂-AR/Gi/GRK2 signal pathway attenuated β₁-AR sustained activation induced by β₁-adrenergic receptor autoantibody

Hao Chen
Ning Cao
Huirong Liu
ResearchOpen Access08 Nov 2021
Cell Death Discovery

Volume: 7, P: 1-11
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

Ying Yang
Lulu Hu
Yanhui Xu
Research22 Jun 2010
Cell Research

Volume: 20, P: 886-898

Search

Molecular characterization and prognostic implications of KRAS mutations in pancreatic cancer patients: insights from multi-cohort analysis

Structural insights into TSC complex assembly and GAP activity on Rheb

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

Superior field performance of waxy corn engineered using CRISPR–Cas9

Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders

Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist

Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

Hirschsprung’s disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β

Autoantibody against β₁-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4⁺ T cells by up-regulating AMPK-mediated fatty acid oxidation

Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults

Cryo-EM structure of human mTOR complex 2

A modular chemoenzymatic cascade strategy for the structure-customized assembly of ganglioside analogs

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

Wuschel2 enables highly efficient CRISPR/Cas-targeted genome editing during rapid de novo shoot regeneration in sorghum

Structure of the human RNA polymerase I elongation complex

Structural insight into substrate recognition by histone demethylase LSD2/KDM1b

Increased AT₂R expression is induced by AT₁R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration

Tomato UV-B receptor SlUVR8 mediates plant acclimation to UV-B radiation and enhances fruit chloroplast development via regulating SlGLK2

Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion

Decreased autophagy induced by β₁-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis

Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis

Biased activation of β₂-AR/Gi/GRK2 signal pathway attenuated β₁-AR sustained activation induced by β₁-adrenergic receptor autoantibody

Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

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