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Showing 1–4 of 4 results
Advanced filters: Author: Huixun Du Clear advanced filters

  • As more spaceflight missions plan to take humans back to the moon — and beyond — a key goal is to understand how spaceflight affects the immune system. In this Review, researchers from academia and international space agencies discuss the emergence of the field of ‘astroimmunology’. They outline the main immunological challenges we must overcome to facilitate safe space exploration by humans.

    • Daniel A. Winer
    • Huixun Du
    • Brian E. Crucian
    Reviews
    Nature Reviews Immunology
    P: 1-24

  • The phenotype and function of immune cells could change during spaceflight. Here the authors use simulated microgravity, coupled to validation with spaceflight data, to assess whether there are distinct gene expression changes in resting and TLR 7/8 stimulated PBMCs and found conserved changes in IFN signalling, the cytoskeleton, IL-6 and sirtuin signalling.

    • Fei Wu
    • Huixun Du
    • Daniel A. Winer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • This Review considers how the biophysical properties of a tissue are able to shape immune cell function through the process of mechanotransduction. There are multiple mechanotransduction pathways that operate in immune cells and the authors highlight these and the emerging field of mechanoimmunology.

    • Huixun Du
    • Juliet M. Bartleson
    • Manish J. Butte
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 174-188