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Showing 1–4 of 4 results
Advanced filters: Author: Hunkar Gizem Yesilyurt Clear advanced filters

  • Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.

    • Elena E. Grintsevich
    • Hunkar Gizem Yesilyurt
    • Emil Reisler
    Research
    Nature Cell Biology
    Volume: 18, P: 876-885

  • Terman and colleagues employed a genetic screen in Drosophila to identify the SelR methionine sulfoxide reductase as the enzyme responsible for reversing the Mical-mediated oxidation of actin. Thus, SelR antagonizes the effects of Semaphorin–Plexin–Mical-dependent signalling in vivo.

    • Ruei-Jiun Hung
    • Christopher S. Spaeth
    • Jonathan R. Terman
    Research
    Nature Cell Biology
    Volume: 15, P: 1445-1454

  • MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.

    • Elena E. Grintsevich
    • Peng Ge
    • Emil Reisler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10