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An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines

Progenitors of intraepithelial T cells (IELps) migrate from the thymus to the intestines after birth where they can develop into unconventional intraepithelial lymphocytes. Here Ocon et al. find that the neuroendocrine peptide hormone somatostatin controls the migration of committed SSTR2-expressing IELps from the thymus to the immature gut.

Borja Ocón
Kevin F. Brulois
Eugene C. Butcher
Research26 Mar 2025
Nature Immunology

Volume: 26, P: 607-618
CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

Plasmacytoid dendritic cells are best known as potent producers of type I interferon. Butcher and colleagues identify a subset of these cells, characterized by CCR9 expression, that can elicit tolerance in the gut.

Husein Hadeiba
Tohru Sato
Eugene C Butcher
Research05 Oct 2008
Nature Immunology

Volume: 9, P: 1253-1260
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

The detrimental effects of aged blood on cognition and nervous system function in mice can be combatted by targeting brain endothelial cell dysfunction via inhibition of aberrant VCAM1 signaling at the blood–brain barrier.

Hanadie Yousef
Cathrin J. Czupalla
Tony Wyss-Coray
Research13 May 2019
Nature Medicine

Volume: 25, P: 988-1000
Deletion of a coordinate regulator of type 2 cytokine expression in mice

Markus Mohrs
Catherine M. Blankespoor
Richard M. Locksley
Research01 Sept 2001
Nature Immunology

Volume: 2, P: 842-847
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

The chemoattractant receptor GPR15 can direct CD4⁺ T cells to the colon. Habtezion and colleagues show that GATA-3 and Foxp3 exhibit species-specific differences in promoting GPR15 expression and thereby influences homing of CD4⁺ effector and regulatory T cells.

Linh P Nguyen
Junliang Pan
Aida Habtezion
Research22 Dec 2014
Nature Immunology

Volume: 16, P: 207-213
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Lahl and colleagues characterize human gut DC populations and define their relationship to previously described human and mouse DCs.

Payal B Watchmaker
Katharina Lahl
Eugene C Butcher
Research01 Dec 2013
Nature Immunology

Volume: 15, P: 98-108

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An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Deletion of a coordinate regulator of type 2 cytokine expression in mice

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

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