The medial prefrontal cortex (mPFC) has been implicated in both social and nonsocial reward-related behaviors, yet it is unclear if the same mPFC neurons represent both types of rewards. Combining a social-sucrose operant assay with calcium imaging and optogenetics, the authors show that largely non-overlapping neurons represent social and sucrose rewards in the mPFC.
- Jennifer Isaac
- Sonia Corbett Karkare
- Malavika Murugan