Herein, we provide a simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategy to obtain radionuclide-embedded gold nanoparticles (RIe-AuNPs) with a high radiosensitivity and excellent in vivo stability. The migration of DCs labeled with RIe-AuNPs to draining lymph nodes was monitored very sensitively and for a long time. The biological function of DCs labeled with RIe-AuNP was not altered and it showed strong antitumor immunity. Because of densely conjugated radioisotopes in RIe-AuNPs, we could obtain strong Cerenkov optical signal comparable with that of positron emission tomography.
- Sang Bong Lee
- Su Bi Ahn
- Yong Hyun Jeon
