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GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

The transcription factor GATA-binding protein 3 (GATA3) is best known as a master regulator of T-helper-2-cell differentiation. However, as part of a network of other transcription factors, GATA3 is also important in determining cell fate at earlier stages of haematopoiesis and lymphoid-cell development.

I-Cheng Ho
Tzong-Shyuan Tai
Sung-Yun Pai
Reviews01 Feb 2009
Nature Reviews Immunology

Volume: 9, P: 125-135
Erratum: IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ Foxp3⁻ effector T cells

Valérie Dardalhon
Amit Awasthi
Vijay K Kuchroo
Amendments and Corrections01 May 2009
Nature Immunology

Volume: 10, P: 551
IL-4 inhibits TGF-β-induced Foxp3⁺ T cells and, together with TGF-β, generates IL-9⁺ IL-10⁺ Foxp3⁻ effector T cells

Foxp3 is required for the generation and function of regulatory T cells. Kuchroo and colleagues find that interleukin 4 blocks the generation of these cells but promotes T helper cells that produce interleukins 9 and 10.

Valérie Dardalhon
Amit Awasthi
Vijay K Kuchroo
Research09 Nov 2008
Nature Immunology

Volume: 9, P: 1347-1355
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

Characterisation of the human antibody response to SARS-CoV-2 can help the design of serological tests and vaccines. Here, the authors identify two linear epitopes in SARS-CoV-2 spike protein that elicit neutralising antibodies in several patients and could thus be useful for serology and vaccine development.

Chek Meng Poh
Guillaume Carissimo
Lisa F. P. Ng
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-7
ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivation

Jia-Shu Yang
Jia-Wei Hsu
Victor W. Hsu
ResearchOpen Access06 Sept 2019
Nature Communications

Volume: 10, P: 1-16
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and T_H-17 cells

The costimulatory molecule ICOS is important for the development of both interleukin 17–producing and follicular T helper cells. Kuchroo and colleagues find that ICOS induces the transcription factor c-Maf, which regulates the population expansion of both helper cell types.

Aurelie T Bauquet
Hulin Jin
Vijay K Kuchroo
Research21 Dec 2008
Nature Immunology

Volume: 10, P: 167-175
Reversible redox reactions in an epitaxially stabilized SrCoO_x oxygen sponge

Low-temperature redox reactions in solids resulting in no thermomechanical degradation can be used to enhance the performance and lifetime of energy devices. Rapid and reversible redox activity has now been demonstrated at temperatures as low as 200 °C in both epitaxially stabilized oxygen-vacancy-ordered SrCoO_2.5 and thermodynamically unfavourable perovskite SrCoO_3−δ single-crystalline thin films.

Hyoungjeen Jeen
Woo Seok Choi
Ho Nyung Lee
Research25 Aug 2013
Nature Materials

Volume: 12, P: 1057-1063
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

Interleukins 4 and 13 are critical for responses to helminthes. Locksley and colleagues use genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo.

Hong-Erh Liang
R Lee Reinhardt
Richard M Locksley
Research04 Dec 2011
Nature Immunology

Volume: 13, P: 58-66
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts

Konstantin Tsoyi
Anthony J. Esposito
Ivan O. Rosas
ResearchOpen Access18 Feb 2022
Scientific Reports

Volume: 12, P: 1-11
Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms

Tzong-Shyuan Tai
Hsiao-Wei Tsao
I-Cheng Ho
Correspondence05 Mar 2020
Cellular & Molecular Immunology

Volume: 17, P: 1198-1200

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