Gastrointestinal stromal tumours (GIST) are the most frequent of all sarcomas. In this Primer, Blay et al. present an overview of epidemiology, mechanisms of tumorigenesis and molecular subtypes of GIST. They discuss state-of-the-art GIST diagnosis and treatment, means to improve patient quality of life and outstanding research questions.
- Jean-Yves Blay
- Yoon-Koo Kang
- Margaret von Mehren