Reversible mRNA methylation is an emerging mode of eukaryotic post-transcriptional gene regulation.N6-methyladenosine (m6A) affects mRNA processing, translation and decay during cell differentiation, embryonic development and stress responses. Other mRNA modifications — N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine — together with m6A code a new layer of information that controls protein synthesis.
- Boxuan Simen Zhao
- Ian A. Roundtree
- Chuan He
